We present a search for the associated production of a standard model Higgs boson and a top quark-anti quark pair ($\mathrm{t}\overline{\mathrm{t}}\mathrm{H}$), using LHC pp collision data collected by the CMS experiment at a center of mass energy of \sqrt{s}=13~\mathrm{TeV} in 2016. The dataset corresponds to an integrated luminosity of 12.9\,\mathrm{fb}^{-1}. The analysis uses events with two leptons of the same charge or at least three charged leptons, produced together with b jets, targeting Higgs boson decay modes to $\mathrm{WW}^{*}$, $\mathrm{ZZ}^{*}$, and $\tau\tau$ and leptonic decays of at least one of the top quarks. The results are combined with the 2015 dataset and yield a $\mathrm{t}\overline{\mathrm{t}}\mathrm{H}$ signal strength of $2.0 {}^{+0.8} {}_{-0.7}$ times the standard model prediction. They are used to set a $95\%$ confidence level upper limit on the signal production cross section of $3.4$ times the standard model expectation, compared to an expected upper limit of $1.3 {}^{+0.6} {}_{-0.4}$ in the absence of a signal.

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